The Association between Montreal Cognitive Assessment Memory Scores and Hippocampal Volume in a Neurodegenerative Disease Sample
نویسندگان
چکیده
Despite widespread use, there have been few investigations into the neuroanatomical correlates of the Montreal Cognitive Assessment (MoCA). In a sample of 138 consecutive patients presenting with cognitive complaints, we report significant correlations between lower MoCA memory scores and smaller hippocampal volumes (r = 0.36-0.41, p < 0.001). We also report that the newly devised memory index score, designed to better capture encoding deficits than the standard delayed recall score, was not significantly better for predicting hippocampal volume. These initial results suggest that poor performance on the MoCA's memory section should prompt further evaluation for hippocampal atrophy.
منابع مشابه
Correlation of MRI findings and cognitive function in multiple sclerosis patients using montreal cognitive assessment test
Background: Magnetic resonance imaging (MRI) has improved the diagnosis and management of patients with multiple sclerosis (MS). Montreal Cognitive Assessment (MoCA) is a brief, sensitive test that has been recommended by National Institute of Neurological Diseases and Stroke and Canadian Stroke Network (NINDS-CSN) as a reliable tool to detect mild cognitive impairments. This study aimed to eva...
متن کاملCognitive Aging and the Hippocampus in Older Adults
The hippocampus is one of the most well studied structures in the human brain. While age-related decline in hippocampal volume is well documented, most of our knowledge about hippocampal structure-function relationships was discovered in the context of neurological and neurodegenerative diseases. The relationship between cognitive aging and hippocampal structure in the absence of disease remain...
متن کاملEvaluation of Cognitive Abilities of Different Groups of Sclerosis Patients and Its Comparison With Healthy People
Objective: Sclerosis is a neurodegenerative disease that is important in measuring and evaluating the cognitive abilities of its patients. Therefore, the diagnostic dimensions of functional differences in cognitive abilities of subgroups of this disease are important. Methods: The research was done with post-event design. The sample consisted of 60 subjects from different groups of patie...
متن کاملThe Relationship Between Memory Impairment and Health Indicators of the Elderly With Parkinson Disease
Objectives Parkinson Disease (PD) is a progressive neurodegenerative disorder affecting motor and cognitive functions. Cognitive impairments are related to different causes such as health indicators. This study aimed to examine the relationship between cognitive impairment and health indicators of patients with PD. Methods & Materials This study was a cross-sectional and descriptive study. B...
متن کاملSimvastatin Attenuates Hippocampal MMP-9 Expression in the Streptozotocin-Induced Cognitive Impairment
Background: Matrix metalloproteinase-9 (MMP-9) expression has been implicated in molecular mechanisms of neurodegenerative disorders, and its abnormal level has been reported in Alzheimer’s disease (AD). Some protective mechanisms of statins against neurodegeneration might be mediated by the inhibition of MMP-9 expression. Here, we investigated the effect of simvastatin, on the hippocampal MMP-...
متن کامل